Epigenetic regulation in cardiac fibrosis.

Abstract

Cardiac fibrosis represents an adoptive response in the heart exposed to various stress cues. While resolution of the fibrogenic response heralds normalization of heart function, persistent fibrogenesis is usually associated with progressive loss of heart function and eventually heart failure. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix proteins, a process the epigenetic machinery plays a pivotal role. In this mini-review, we summarize recent advances regarding the epigenetic regulation of cardiac fibrosis focusing on the role of histone and DNA modifications and non-coding RNAs.

• Authors: Li-Ming Yu, Yong Xu
• Journal: World journal of cardiology (World J Cardiol) Vol. 7 Issue 11 Pg. 784-91 (Nov 26 2015) ISSN: 1949-8462 [Print] United States
• PMID: 26635926 (Publication Type: Journal Article, Review)