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Monotherapy with labetalol for hypertensive patients with normal and impaired renal function.

Abstract
1 Labetalol was given to 41 hypertensive patients in a divided dosage of 150-2,400 mg daily for periods ranging from 1-64 months. 2 Monotherapy with labetalol was adequate in 12 out of 19 patients with essential hypertension and in 15 out of the 22 with renal hypertension. 3 Following a single dose of labetalol 200 mg orally a hypotensive response was seen between 1.5 and 2 hours. 4 In the doses used there was no exercise or postural hypotension. 5 No reduction in overall renal function attributable to labetalol was seen.
AuthorsF D Thompson, A M Joekes, M M Hussein
JournalBritish journal of clinical pharmacology (Br J Clin Pharmacol) Vol. 8 Suppl 2 Pg. 129S-33S (Apr 1979) ISSN: 0306-5251 [Print] England
PMID26635153 (Publication Type: Journal Article)
Copyright1979 The British Pharmacological Society.

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