Expression and Prognostic Significance of Macrophage Inflammatory Protein-3 Alpha and Cystatin A in Nasopharyngeal Carcinoma.

Abstract

This study aims to investigate the expression of macrophage inflammatory protein-3 alpha (MIP-3α) and cystatin A in nasopharyngeal carcinoma (NPC) and their association with clinical characteristics and prognosis. Primary tumor specimens from 114 NPC patients and associated clinical follow-up data were collected, and the expression of MIP-3α and cystatin A proteins was investigated by immunohistochemistry. Expression of MIP-3α was significantly associated with TNM stage in patients with NPC (P < 0.05). NPC patients with positive expression of MIP-3α exhibited shorter median overall survival (OS) and distant metastasis-free survival (DMFS), compared with patients with negative expression (OS: 50.5 months versus 59.0 months, P = 0.013; DMFS: 50.1 months versus 60.2 months, P = 0.003). NPC patients with positive expression of cystatin A exhibited shorter median OS, local recurrence-free survival (LRFS), and DMFS, compared with patients with negative expression (OS: 51.1 months versus 60.0 months, P = 0.004; LRFS: 54.5 months versus 59.5 months, P = 0.036; DMFS: 52.3 months versus 58.8 months, P = 0.036). Both MIP-3α and cystatin A overexpressions in NPC tumor tissues were strong independent factors of poor prognosis in NPC patients. MIP-3α and cystatin A expressions may be valuable prognostic markers in NPC patients.

• Authors: Minzhong Tang, Ningjiang Ou, Cheng Li, Aiying Lu, Jun Li, Liping Ma, Weiming Zhong, Jianquan Gao, Yuming Zheng, Yonglin Cai
• Journal: BioMed research international (Biomed Res Int) Vol. 2015 Pg. 617143 ( 2015) ISSN: 2314-6141 [Electronic] United States
• PMID: 26634210 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• CCL20 protein, human
• Chemokine CCL20
• Cystatin A
• CSTA protein, human

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Carcinoma
• Chemokine CCL20 (metabolism)
• China (epidemiology)
• Cystatin A (metabolism)
• Female
• Humans
• Male
• Middle Aged
• Nasopharyngeal Carcinoma
• Nasopharyngeal Neoplasms (metabolism, mortality, radiotherapy)
• Prevalence
• Prognosis
• Reproducibility of Results
• Risk Assessment (methods)
• Sensitivity and Specificity
• Survival Rate
• Treatment Outcome