CLINICAL APPLICATION OF L-MENTHOL IN THE UPPER GASTROINTESTINAL ENDOSCOPIC PROCEDURE.

Abstract

AIM:

Peppermint oil, which suppresses gastric peristalsis during esophagogastroduodenoscopy (EGD), is effective for determining the margin of a gastric tumor. This study was conducted to evaluate the utility of an L-menthol preparation for suppressing gastric peristalsis and for diagnosing gastric tumors.

METHODS:

The study examined 124 patients who underwent EGD between January and April 2012. After 20 mL of 0.8% L-menthol was sprayed directly onto the mucosal surface of the gastric antrum, the degree of peristalsis suppression in the antrum was evaluated. The effectiveness of L-menthol for identifying new gastric tumors and determining tumor margins was also evaluated.

RESULTS:

Gastric peristalsis was suppressed in 88.5% (69/78) of patients, with complete suppression of peristalsis achieved in 78.2%. L-menthol exerted a higher peristalsis-suppressive effect in patients with endoscopic gastric mucosal atrophy (93.3%, 56/60) than in patients without atrophy (72.2%, 13/18) (p = .014). L-menthol application caused the detection of new gastric tumors in 1.6% (2/124) of patients and clarification of the margin of three lesions (in 3 patients) identified as having an unclear margin before L-menthol application.

CONCLUSION:

These results suggest that L-menthol is effective for suppressing gastric peristalsis during EGD and suggest that it is useful for identifying gastric tumors and for determining tumor margins.

• Authors: Hitomi Kikuchi, Takuto Hikichi, Tadayuki Takagi, Rei Suzuki, K O Watanabe, Jun Nakamura, Mitsuru Sugimoto, Yuichi Waragai, Naoki Konno, Hiroyuki Asama, Mika Takasumi, Hiroshi Watanabe, Katsutoshi Obara, Hiromasa Ohira
• Journal: Fukushima journal of medical science (Fukushima J Med Sci) Vol. 61 Issue 2 Pg. 160-6 ( 2015) ISSN: 2185-4610 [Electronic] Japan
• PMID: 26632191 (Publication Type: Journal Article)

Chemical References

• Menthol

Topics

• Aged
• Endoscopy, Digestive System
• Female
• Humans
• Male
• Menthol
• Stomach Neoplasms (diagnosis)