Abstract | BACKGROUND:
Obesity is not a homogeneous condition across individuals since about 25-40% of obese individuals can maintain healthy status with no apparent signs of metabolic complications. The simple anthropometric measure of body mass index does not always reflect the biological effects of excessive body fat on health, thus additional molecular characterizations of obese phenotypes are needed to assess the risk of developing subsequent metabolic conditions at an individual level. METHODS: To better understand the associations of free fatty acids (FFAs) with metabolic phenotypes of obesity, we applied a targeted metabolomics approach to measure 40 serum FFAs from 452 individuals who participated in four independent studies, using an ultra-performance liquid chromatograph coupled to a Xevo G2 quadruple time-of-flight mass spectrometer. FINDINGS: INTERPRETATION: These findings underscore the potential role of UFAs in the MS pathogenesis and also as important markers in predicting the risk of developing diabetes in obese individuals or diabetes remission after a metabolic surgery.
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Authors | Yan Ni, Linjing Zhao, Haoyong Yu, Xiaojing Ma, Yuqian Bao, Cynthia Rajani, Lenora W M Loo, Yurii B Shvetsov, Herbert Yu, Tianlu Chen, Yinan Zhang, Congrong Wang, Cheng Hu, Mingming Su, Guoxiang Xie, Aihua Zhao, Wei Jia, Weiping Jia |
Journal | EBioMedicine
(EBioMedicine)
Vol. 2
Issue 10
Pg. 1513-22
(Oct 2015)
ISSN: 2352-3964 [Electronic] Netherlands |
PMID | 26629547
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Fatty Acids, Unsaturated
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Topics |
- Adult
- Biomarkers
- Chromatography, High Pressure Liquid
- Cluster Analysis
- Diabetes Mellitus, Type 2
(blood, complications)
- Fatty Acids, Unsaturated
(blood)
- Female
- Humans
- Male
- Metabolic Syndrome
(blood, etiology)
- Metabolome
- Metabolomics
(methods)
- Middle Aged
- Obesity
(blood, complications, diet therapy, metabolism)
- Odds Ratio
- Overweight
(blood, complications)
- Phenotype
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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