Microenviromental change after synthetic E-selectins interfere in ischemia-reperfusion in rats and its contribution to endogenetic/exogenous never stem cells.

Abstract

OBJECTIVE:

To explore the special significances in advantages of using anti-inflammatory drugs, such as amelioration of growing conditions and the promotion of cell growth.

METHODS:

Utilizing anti-adhesive effects of synthetic E-selectins, we observed the changes of inflammatory cytokines (TNF-α, IL-1β) contented in brain tissues and rat serums in rats hind cerebral ischemia-reperfusion models. Both growth and expression of endogenetic/exogenous neurological stem cells were detected after ameliorated local microenvironment.

RESULTS:

The contents of TNF-α and IL-1β were decreased in brain tissues and rat serums after applying synthetic E-selectins. Expression of exogenous neurological stem cells was enhanced. Animal neurological functions improved.

CONCLUSION:

Anti-inflammatory therapy in early stage could enhance proliferation of stem cells so that it has vital significations in treating cerebrovascular diseases.

• Authors: Wei-Hua Lin, Feng Xu, Long Bao, Shi-Ying Zheng, Wen-Ming Shen
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 9 Pg. 11847-53 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26617939 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Inflammatory Agents
• E-Selectin
• IL1B protein, rat
• Interleukin-1beta
• Neuroprotective Agents
• Tumor Necrosis Factor-alpha

Topics

• Animals
• Anti-Inflammatory Agents (chemical synthesis, pharmacology)
• Brain (drug effects, metabolism, pathology, physiopathology)
• Brain Ischemia (blood, drug therapy, pathology, physiopathology)
• Cell Proliferation (drug effects)
• Cytoprotection
• Disease Models, Animal
• E-Selectin (pharmacology)
• Female
• Interleukin-1beta (blood)
• Male
• Neural Stem Cells (drug effects, metabolism, pathology)
• Neuroprotective Agents (chemical synthesis, pharmacology)
• Rats, Sprague-Dawley
• Recovery of Function
• Reperfusion Injury (blood, pathology, physiopathology, prevention & control)
• Stem Cell Niche
• Time Factors
• Tumor Necrosis Factor-alpha (blood)