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Association of long non-coding RNA HOTTIP with progression and prognosis in colorectal cancer.

Abstract
Long non-coding RNA (lncRNA) has an important role in carcinoma progression and prognosis. However, little is known about the pathological role of lncRNA HOTTIP (HOXA transcript at the distal tip) in colorectal cancer (CRC) patients. This study attempted to investigate the association of lncRNA HOTTIP expression with progression and prognosis in CRC patients. LncRNA HOTTIP expression was measured in 156 CRC tissues and 21 adjacent non-malignant tissues using qRT-PCR. In present study, our results indicated that lncRNA HOTTIP was highly expressed in CRC compared with adjacent non-malignant tissues (P<0.001), and positively correlated with T stage (T1-2 vs. T3-4, P = 0.001), clinical stage (I-II stages vs. III-IV stages, P = 0.003), and distant metastasis (absent vs. present, P = 0.014) in CRC patients. Furthermore, we also observed that increased lncRNA HOTTIP expression was an unfavorable prognostic factor in CRC patients (P = 0.001), regardless of T stage, distant metastasis and clinical stage. Finally, overexpression of lncRNA HOTTIP was supposed to be an independent poor prognostic factor for CRC patients through multivariate analysis (P = 0.017). In conclusion, lncRNA HOTTIP overexpression maybe serves as an unfavorable prognosis predictor for CRC patients. However, a further larger sample size investigation is needed to support our results.
AuthorsYing-Kun Ren, Yan Xiao, Xiang-Bin Wan, Yu-Zhou Zhao, Jian Li, Yin Li, Guang-Sen Han, Xiao-Bing Chen, Qi-Yun Zou, Gang-Cheng Wang, Chao-Min Lu, Yong-Chao Xu, You-Cai Wang
JournalInternational journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 9 Pg. 11458-63 ( 2015) ISSN: 1936-2625 [Electronic] United States
PMID26617875 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • RNA, Long Noncoding
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (analysis, genetics)
  • Colorectal Neoplasms (genetics, mortality, pathology)
  • Disease Progression
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Prognosis
  • Proportional Hazards Models
  • RNA, Long Noncoding (analysis, biosynthesis)
  • Real-Time Polymerase Chain Reaction

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