SP-D, KL-6, and HTI-56 levels in children with mycoplasma pneumoniae pneumonia.

Abstract

UNLABELLED:

The study was aimed to evaluate the potential biomarkers from pulmonary surfactant protein D (SP-D), Krebs von den Lungen-6 (KL-6), and 56-kD a human type I protein (HTI-56) in serum and bronchoalveolar lavage fluid samples of children with Mycoplasma pneumoniae pneumonia. This retrospective study, self-controlled study enrolled 34 Chinese children with M. pneumoniae pneumonia. The levels of SP-D, KL-6, and HTI-56 in bronchoalveolar lavage fluid samples were assessed and compared between patients with unilateral lung infection and contralateral lungs without any abnormal findings. Significant differences in the levels of SP-D, KL-6, and HTI-56 were observed in infected bronchoalveolar lavage fluid samples compared with uninfected samples (all P<0.05); however, there was no correlation between the serum level of SP-D, KL-6, and HTI-56 and their levels in infected and uninfected bronchoalveolar lavage fluid samples (P>0.05).

CONCLUSION:

The high levels of SP-D, KL-6, and HTI-56 in infected bronchoalveolar lavage fluid samples may reflect the injury of alveolar epithelium caused by M. pneumoniae. Instead of SP-D in uninfected bronchoalveolar lavage fluid samples obtained by invasive bronchoscopy, serum SP-D may serve as a convenient medium to distinguish lung infection caused by M. pneumoniae.

• Authors: Lin-Hua Shu, Quan Lu, Li-Ying Han, Guang-Hui Dong
• Journal: International journal of clinical and experimental pathology (Int J Clin Exp Pathol) Vol. 8 Issue 9 Pg. 11185-91 ( 2015) ISSN: 1936-2625 [Electronic] United States
• PMID: 26617840 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• HTI56 protein, human
• MUC1 protein, human
• Membrane Proteins
• Mucin-1
• Pulmonary Surfactant-Associated Protein D

Topics

• Adolescent
• Age Factors
• Biomarkers (blood)
• Bronchoalveolar Lavage Fluid (chemistry)
• Bronchoscopy
• Child
• Child, Preschool
• China
• Female
• Humans
• Infant
• Male
• Membrane Proteins (blood)
• Mucin-1 (blood)
• Mycoplasma pneumoniae (pathogenicity)
• Pneumonia, Mycoplasma (blood, diagnosis, microbiology)
• Predictive Value of Tests
• Pulmonary Surfactant-Associated Protein D (blood)
• Retrospective Studies
• Tomography, X-Ray Computed