Response to low dose indomethacin in two children with nephrogenic diabetes insipidus.

Abstract

Two children with nephrogenic diabetes insipidus (NDI) were treated with oral indomethacin (0.75-1.2 mg/kg/day) three times a day for a mean duration of 3 yrs. Remission occurred in both patients in terms of achieving a normal fluid balance and body growth and the drug was withdrawn in one patient after 2 yrs. The treatment was well tolerated and no side effects were noted. The mean duration of follow-up was 6.5 yrs. These long-term observations of a favourable response to low dose indomethacin in 2 children with NDI need to be tested on larger number of patients.

• Authors: Devi Dayal, Savita Verma Attri, Anil Kumar Bhalla, Rakesh Kumar
• Journal: Pediatric endocrinology, diabetes, and metabolism (Pediatr Endocrinol Diabetes Metab) Vol. 20 Issue 4 Pg. 178-81 ( 2015) ISSN: 2081-237X [Print] Poland
• PMID: 26615585 (Publication Type: Case Reports, Journal Article)
• Copyright: © Polish Society for Pediatric Endocrinology and Diabetology.

Chemical References

• Indomethacin

Topics

• Child
• Child, Preschool
• Diabetes Insipidus, Nephrogenic (diagnosis, drug therapy)
• Dose-Response Relationship, Drug
• Humans
• Indomethacin (therapeutic use)
• Male
• Poland
• Treatment Outcome