Single dose of diclofenac or meloxicam for control of pain, facial swelling, and trismus in oral surgery.

Abstract

BACKGROUND:

Postoperative pain associated with removal of mandibular third molars has been documented from moderate to severe during the first 24 hours after surgery, with pain peaking between 6 and 8 hours when a conventional local anesthetic is used. Dental pain is largely inflammatory, and evidence-based medicine has shown that nonsteroidal anti-inflammatory drugs are the best analgesics for dental pain. The aim of this study was to compare the analgesic, anti-inflammatory and anti-trismus effect of a single dose of diclofenac and meloxicam after mandibular third molar extraction.

MATERIAL AND METHODS:

A total of 36 patients were randomized into two treatment groups, each with 18 patients, using a series of random numbers: Group A, was administered 100 mg of diclofenac; and Group B, 15 mg of meloxicam. Drugs were administered orally 1 hour prior to surgery. We evaluated pain intensity, analgesic consumption, swelling, as well as trismus.

RESULTS:

The results of this study showed that patients receiving 15 mg of meloxicam had less postoperative pain (P=0.04) and better aperture than those receiving 100 mg of diclofenac (P=0.03). The meloxicam group presented less swelling than diclofenac group; however, significant statistical differences were not observed.

CONCLUSIONS:

Data of this double-blind, randomized, parallel-group clinical trial demonstrated that patients receiving 15 mg of preoperative meloxicam had a better postoperative analgesia and anti-trismus effect compared with who were given 100 mg of diclofenac after third molar extractions.

• Authors: Mariana Orozco-Solís, Yazmín García-Ávalos, Celeste Pichardo-Ramírez, Francisco Tobías-Azúa, Juan-Ramón Zapata-Morales, Othoniel-Hugo Aragon-Martínez, Mario-Alberto Isiordia-Espinoza
• Journal: Medicina oral, patologia oral y cirugia bucal (Med Oral Patol Oral Cir Bucal) Vol. 21 Issue 1 Pg. e127-34 (Jan 01 2016) ISSN: 1698-6946 [Electronic] Spain
• PMID: 26615509 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Thiazines
• Thiazoles
• Diclofenac
• Meloxicam

Topics

• Adolescent
• Adult
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Diclofenac (administration & dosage)
• Double-Blind Method
• Edema (etiology, prevention & control)
• Female
• Humans
• Male
• Meloxicam
• Molar, Third (surgery)
• Pain, Postoperative (etiology, prevention & control)
• Thiazines (administration & dosage)
• Thiazoles (administration & dosage)
• Tooth Extraction (adverse effects)
• Trismus (etiology, prevention & control)
• Young Adult