Abstract | BACKGROUND: In patients who are not amenable to surgical resection (cavernostomy), it is difficult to achieve palliation of hemoptysis from pulmonary aspergilloma. There are only 9 cases with a short follow-up that have reported the use of radiotherapy for hemoptysis in this scenario. METHODS: RESULTS: The median time between tuberculosis treatment and the onset of hemoptysis due to aspergilloma was 9 years. After radiotherapy, general status improved and the hemoptysis resolved in all patients. During the follow-up period, 4 failures occurred, with a 5-year local failure-free survival rate of 82 % and a 5-year overall survival rate of 59 %. Of these failures, 2 patients died due to recurrence of the hemoptysis, and 2 were rescued (using cavernostomy and reirradiation). The presence of chronic obstructive pulmonary disease ( COPD) (p = 0.021) and female gender (p = 0.032) were negatively associated with overall survival. None of the variables was related to local control. CONCLUSIONS: Based on these long-term data, radiotherapy is a potential option for controlling bleeding due to fungus balls. Female patients and COPD were associated with lower survival.
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Authors | Lucas G Sapienza, Maria José L Gomes, Carmelindo Maliska, Antonio N Norberg |
Journal | BMC infectious diseases
(BMC Infect Dis)
Vol. 15
Pg. 546
(Nov 26 2015)
ISSN: 1471-2334 [Electronic] England |
PMID | 26612361
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Antitubercular Agents
(therapeutic use)
- Female
- Follow-Up Studies
- Hemoptysis
(diagnosis, pathology)
- Humans
- Invasive Pulmonary Aspergillosis
(diagnosis, mortality, radiotherapy)
- Kaplan-Meier Estimate
- Lung
(diagnostic imaging)
- Male
- Middle Aged
- Pulmonary Disease, Chronic Obstructive
(complications)
- Retrospective Studies
- Sex Factors
- Tomography, X-Ray Computed
- Tuberculosis
(pathology)
- Tuberculosis, Pulmonary
(drug therapy)
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