Corticosteroids in Lupus Nephritis and Central Nervous System Lupus.

Abstract

Corticosteroids are a mainstay of therapy for severe organ-threatening systemic lupus erythematosus. Lupus nephritis and central nervous system (CNS) lupus remain two of the most debilitating and potentially life-threatening manifestations of lupus. The dose and duration of corticosteroids required for control of lupus nephritis and CNS lupus have never been tested in a randomized trial design, so current recommendations are based on observation and expert opinion. As more targeted individualized therapeutic approaches are developed for lupus nephritis and CNS lupus, reliance on long-term corticosteroids will decrease, as will the long-term damage and early mortality associated with their use.

• Authors: Diane L Kamen, Eric S Zollars
• Journal: Rheumatic diseases clinics of North America (Rheum Dis Clin North Am) Vol. 42 Issue 1 Pg. 63-73, viii (Feb 2016) ISSN: 1558-3163 [Electronic] United States
• PMID: 26611551 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Glucocorticoids
• Immunosuppressive Agents

Topics

• Adrenal Cortex Hormones (administration & dosage, therapeutic use)
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Immunosuppressive Agents (administration & dosage, therapeutic use)
• Lupus Nephritis (drug therapy)
• Lupus Vasculitis, Central Nervous System (drug therapy)
• Severity of Illness Index