Abstract |
Our previous studies indicated an increase in extracellular γ- aminobutyric acid ( GABA) in rodent's ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor (GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam.
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Authors | Pallab Bhattacharya, Anand Kumar Pandey, Sudip Paul, Ranjana Patnaik |
Journal | Neural regeneration research
(Neural Regen Res)
Vol. 10
Issue 9
Pg. 1418-20
(Sep 2015)
ISSN: 1673-5374 [Print] India |
PMID | 26604901
(Publication Type: Journal Article)
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