Piroxicam-mediated modulatory action of 5-hydroxytryptamine serves as a "brake" on neuronal excitability in ischemic stroke.

Abstract

Our previous studies indicated an increase in extracellular γ-aminobutyric acid (GABA) in rodent's ischemic brain after Piroxicam administration, leading to alleviation of glutamate mediated excitotoxicity through activation of type A GABA receptor (GABAA). This study was to investigate if GABAA activation by Piroxicam affects extracellular 5-hydroxytryptamine or not. High performance liquid chromatography revealed that there was a significant decrease in extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum in Piroxicam pre-treated rat brains. This suggests a probable role of Piroxicam in reducing extracellular 5-hydroxytryptamine release in ischemic cerebral cortex and striatum possibly due to the GABAA activation by Piroxicam.

• Authors: Pallab Bhattacharya, Anand Kumar Pandey, Sudip Paul, Ranjana Patnaik
• Journal: Neural regeneration research (Neural Regen Res) Vol. 10 Issue 9 Pg. 1418-20 (Sep 2015) ISSN: 1673-5374 [Print] India
• PMID: 26604901 (Publication Type: Journal Article)