Clinical observation on treatment of Tourette syndrome in Chinese children by clonidine adhesive patch.

Abstract

OBJECTIVE:

To evaluate the therapeutic effectiveness and safety of clonidine adhesive patch in treating Tourette syndrome (TS).

METHODS:

From July 2010 to July 2014,a total of 261 children, who met the Chinese Classification of Mental Disorders (third edition) diagnostic criteria for TS, aged 5-12 years, were referred to the department of Pediatrics, Shaanxi Provincial People's Hospital. The patients were divided randomly into a treatment group (clonidine adhesive patch, n = 128) and a control group (haloperidol, n = 116), 17cases dropped out. The clinical effectiveness was assessed by the Yale Global Tic Severity Scale (YGTSS) at the end of fourth week. The short-term effectiveness and adverse reaction to the treatment were assessed at the end of treatment.

RESULTS:

The YGTSS score in both groups decreased after 4 weeks of treatment, but the clonidine adhesive patch group showed a higher reduction in the overall tic symptom scores (40.05 ± 3.44%) than that of the control group (17.88 ± 4.40%; P < 0.05). In the clonidine adhesive patch group, the effectiveness was 81.3% (effective in 104 patients), while it was 66.4% in the control group (effective in 77 patients). The overall effectiveness rate showed no statistical significance between the two groups (p > 0.05). There were no severe adverse events in both groups, but mild side effects (decrease of blood pressure and dizziness) were observed in 3 patients in the clonidine adhesive patch group. 2 had mild cervical muscle tension and 4 had mild drowsiness and fatigue in the control group.

CONCLUSION:

In the treatment of TS in children and adolescents, the clonidine adhesive patch is superior to the standard treatment with haloperidol with a safer and better-tolerated profile.

• Authors: Fuyong Jiao, Xiaoyan Zhang, Xipin Zhang, Jing Wang
• Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society (Eur J Paediatr Neurol) Vol. 20 Issue 1 Pg. 80-4 (Jan 2016) ISSN: 1532-2130 [Electronic] England
• PMID: 26602699 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Antipsychotic Agents
• Haloperidol
• Clonidine

Topics

• Antipsychotic Agents (therapeutic use)
• Asian People
• Blood Pressure (drug effects)
• Child
• Child, Preschool
• Clonidine (administration & dosage, therapeutic use)
• Female
• Haloperidol (therapeutic use)
• Humans
• Male
• Psychiatric Status Rating Scales
• Tourette Syndrome (drug therapy)
• Transdermal Patch
• Treatment Outcome