Abstract | INTRODUCTION: METHODS: RESULTS: In total 2086 early arthritis patients were studied regarding the presence of anti-CarP antibodies. We observed that the sensitivity and specificity of the presence of anti-CarP antibodies for RA were 44 % and 89 %, respectively. As a reference, sensitivity and specificity of the presence of anti-CCP2 antibodies were 54 % and 96 %, respectively, and of IgM-RF 59 % and 91 %. Patients harboring anti-CarP antibodies not classified as RA were mainly diagnosed with undifferentiated arthritis and less frequently reactive arthritis and psoriatic arthritis. CONCLUSION: Anti-CarP antibodies are predominantly present in RA but can also be detected in other forms of arthritis.
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Authors | Jing Shi, Hanna W van Steenbergen, Jessica A B van Nies, E W Nivine Levarht, Tom W J Huizinga, Annette H M van der Helm-van Mil, René E M Toes, Leendert A Trouw |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 17
Pg. 339
(Nov 24 2015)
ISSN: 1478-6362 [Electronic] England |
PMID | 26601692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Autoantibodies
- Autoantigens
- Biomarkers
- Cyanides
- Proteins
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Topics |
- Area Under Curve
- Arthritis, Rheumatoid
(immunology)
- Autoantibodies
(blood, immunology)
- Autoantigens
(immunology)
- Biomarkers
(blood)
- Cyanides
(metabolism)
- Enzyme-Linked Immunosorbent Assay
- Humans
- Protein Processing, Post-Translational
(immunology)
- Proteins
(immunology, metabolism)
- ROC Curve
- Sensitivity and Specificity
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