Abstract | BACKGROUND: MATERIALS AND METHODS: Medical records of 7 patients with severe neuropathic pain, in whom many attempts at treatment with approved substances were not sufficient or possible, are reported retrospectively. Patients were then treated with topical ambroxol 20% cream applied in the area of neuropathic pain. RESULTS: CONCLUSION:
Ambroxol acts as a strong local anesthetic and preferentially inhibits the nociceptive-relevant sodium channel subtype Nav 1.8. For the first time, we report relevant pain reduction following topical Ambroxol 20% cream in patients with neuropathic pain. Regarding the advantageous profile with rare side effects, the clinical benefit for pain patients should be further investigated.
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Authors | K-U Kern, T Weiser |
Journal | Schmerz (Berlin, Germany)
(Schmerz)
Vol. 29
Issue 6
Pg. 632-40
(Dec 2015)
ISSN: 1432-2129 [Electronic] Germany |
Vernacular Title | Topisches Ambroxol zur Behandlung neuropathischer Schmerzen: Eine erste klinische Beobachtung. |
PMID | 26597641
(Publication Type: Case Reports, Comparative Study, Journal Article)
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Chemical References |
- Ambroxol
- Lidocaine
- Capsaicin
|
Topics |
- Administration, Topical
- Adult
- Aged
- Aged, 80 and over
- Ambroxol
(administration & dosage, adverse effects)
- Capsaicin
(administration & dosage)
- Female
- Humans
- Lidocaine
(administration & dosage)
- Long-Term Care
- Male
- Middle Aged
- Neuralgia
(drug therapy, etiology)
- Pain Measurement
(drug effects)
- Pain, Postoperative
(drug therapy, etiology)
- Retrospective Studies
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