[The efficacy of intratympanic dexamethasone injection for the moderate and severe sudden deafness with BPPV].

Abstract

OBJECTIVE:

To evaluate the efficacy of intratympanic dexamethasone injection for the moderate and severe sudden deafness with BPPV.

METHOD:

A total of 63 patients diagnosed with sudden sensorineural hearing loss with BPPV were treated through OPD. Patients were divided into three groups: 20 cases in intratympanic dexamethasone injection as initial treatment (group A); 18 cases in systemic hormone therapy group (group B); 25 cases in intratympanic dexamethasone injection as salvage treatment (group C). In addition, routine drugs were used to all patients.

RESULT:

The overall effective rate of group A, B and C in hearing recovery was 60.0%, 38.9% and 48.0%, respectively: (1) No significant difference of hearing recovery was observed among three groups (P > 0.05); (2) A significant difference of hearing recovery was evidenced between group A and C (P < 0.05); (3) A significant difference of hearing recovery was evidenced between group A and C (P < 0.05); (4) No statistically significant difference was found in the hearing recovery between group B and C (P > 0.05).

CONCLUSION:

Our data showed that intratympanic dexamethasone should be used as initial therapy for treating the moderate and severe sudden deafness with BPPV.

• Authors: Xiaowei Zhou, Youjun Yu, Yuanxin Zhao, Yuejian Wang, Zhen Liu, Qiuling Liu
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 29 Issue 10 Pg. 934-6 (May 2015) ISSN: 2096-7993 [Print] China
• PMID: 26596013 (Publication Type: Clinical Study, Journal Article)

Chemical References

• Dexamethasone

Topics

• Benign Paroxysmal Positional Vertigo (complications)
• Dexamethasone (administration & dosage, therapeutic use)
• Hearing Loss, Sensorineural (complications, drug therapy)
• Hearing Loss, Sudden (complications, drug therapy)
• Hearing Tests
• Humans
• Injection, Intratympanic
• Salvage Therapy
• Treatment Outcome