Effect of Octreotide on Colonic Motility in Pediatric Patients With Chronic Recalcitrant Constipation.

Abstract

OBJECTIVE:

The aim of the present study was to study the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis and other suspected colonic motility disorders.

METHODS:

This was a nonrandomized, single-center, open-label, prospective study evaluating the effect of a single subcutaneous dose of octreotide on colonic motility.

RESULTS:

Thirteen patients (5 boys) were enrolled in the study. The age range was 4.6 to 16.2 years. Eleven patients (84%) had normal colonic manometry and 2 patients (16%) had colonic neuropathy. Motility Index (MI) (mmHg) for the 15 minutes before and after octreotide infusion was 6.03 ± 1.26 (95% confidence interval [CI] 5.35-6.72) and 5.32 ± 1.66 (95% CI 4.42-6.23), respectively, with P value of 0.08. MI for the 30 minutes before and after octreotide infusion was 6.89 ± 1.37 (95% CI 6.14-7.64) and 6.71 ± 1.47 (95% CI 5.91-7.52), respectively, with P value of 0.55. MI for the 45 minutes before and after octreotide infusion was 7.73 ± 1.32 (95% CI 7.01-8.45) and 7.53 ± 1.38 (95% CI 6.78-8.28), respectively, with P value of 0.8.

CONCLUSION:

Our study showed that the administration of octreotide resulted in no significant changes in colonic MI in pediatric patients with chronic recalcitrant constipation.

• Authors: Kalyan Ray Parashette, Shamaila Waseem, Debra Horn, Aali Shah, Joseph Croffie
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 61 Issue 6 Pg. 626-9 (Dec 2015) ISSN: 1536-4801 [Electronic] United States
• PMID: 26595852 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Gastrointestinal Agents
• Octreotide

Topics

• Adolescent
• Child
• Child, Preschool
• Colon (drug effects, physiology)
• Colonic Diseases (drug therapy, physiopathology)
• Constipation (drug therapy, physiopathology)
• Encopresis (drug therapy, physiopathology)
• Fecal Incontinence
• Female
• Gastrointestinal Agents (pharmacology, therapeutic use)
• Gastrointestinal Motility (drug effects)
• Humans
• Male
• Manometry
• Octreotide (pharmacology, therapeutic use)
• Prospective Studies