Cellular Players in the Immunopathogenesis of Sarcoidosis.

Abstract

Current hypotheses on the pathogenesis of sarcoidosis assume that it is induced by a nondegradable antigen inducing immune reactions, which are mediated by a panel of immune cells of the innate and adoptive immune system. This immune reaction leads to an accumulation of immune cells that is mainly alveolar macrophages, T cells, and neutrophils in the lung. As the antigen persists and cannot be eliminated, the ongoing immune reaction results in granuloma formation and remodeling of the lung. The current review aims to elucidate the different roles of the cellular players in the immunopathogenesis of sarcoidosis.

• Authors: Gernot Zissel, Joachim Müller-Quernheim
• Journal: Clinics in chest medicine (Clin Chest Med) Vol. 36 Issue 4 Pg. 549-60 (Dec 2015) ISSN: 1557-8216 [Electronic] United States
• PMID: 26593132 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Chemical References

• Cytokines
• Tumor Necrosis Factor-alpha

Topics

• Cytokines
• Humans
• Macrophages, Alveolar (immunology)
• Sarcoidosis (immunology, pathology)
• T-Lymphocytes (immunology)
• Tumor Necrosis Factor-alpha (immunology)