Abstract | AIM: A hyperenhanced rim (termed 'HER') in the postvascular phase is detected in some cases of liver metastasis by Sonazoid-enhanced ultrasonography (US). Here, the association of the HER with histological features was investigated to clarify the cause of this characteristic imaging pattern. SUBJECTS AND METHODS: A total of 13 hepatic nodules obtained from 11 patients with metastatic liver cancer who underwent Sonazoid-enhanced US followed by surgical resection were analyzed. The distribution density of CD68-positive cells in the tumor rim and the nontumor area was calculated and compared between the HER-positive and HER-negative groups. The relation between the pathological features of the tumor rim and the rate of necrosis within the tumor was also investigated. RESULTS: In the HER-positive group (n = 8), the distribution density of CD68-positive cells was 2.9 ± 0.9, which was significantly higher than that (1.0 ± 0.3) in the HER-negative group (p < 0.05). Inflammatory cell infiltrates, including CD8-positive lymphocytes, were detected in all the HER-positive cases in the area surrounding the tumor, while fibrosis was observed in all the HER-negative cases. The necrotic area within the tumor was significantly larger in the HER-negative group. CONCLUSION: The HER-positive sign in liver metastases could reflect an increase in Kupffer cells in the tumor rim. The presence of the HER was associated with inflammatory cell infiltrates including CD8-positive lymphocytes surrounding the metastatic liver tumor.
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Authors | Hitoshi Tochio, Masafumi Sugahara, Yukihiro Imai, Hiroshi Tei, Yoshiyuki Suginoshita, Nobuhiro Imawsaki, Ichiro Sasaki, Michio Hamada, Kazushi Minowa, Tetsuo Inokuma, Masatoshi Kudo |
Journal | Oncology
(Oncology)
Vol. 89 Suppl 2
Pg. 33-41
( 2015)
ISSN: 1423-0232 [Electronic] Switzerland |
PMID | 26584034
(Publication Type: Journal Article)
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Copyright | © 2015 S. Karger AG, Basel. |
Chemical References |
- Contrast Media
- Ferric Compounds
- Oxides
- Sonazoid
- Iron
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Contrast Media
(pharmacokinetics)
- Female
- Ferric Compounds
(pharmacokinetics)
- Follow-Up Studies
- Humans
- Image Enhancement
(methods)
- Iron
(pharmacokinetics)
- Kupffer Cells
(diagnostic imaging, metabolism, pathology)
- Liver Neoplasms
(diagnostic imaging, metabolism, secondary)
- Male
- Middle Aged
- Neoplasm Staging
- Oxides
(pharmacokinetics)
- Prognosis
- Tissue Distribution
- Ultrasonography
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