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Hyperenhanced Rim Surrounding Liver Metastatic Tumors in the Postvascular Phase of Sonazoid-Enhanced Ultrasonography: A Histological Indication of the Presence of Kupffer Cells.

AbstractAIM:
A hyperenhanced rim (termed 'HER') in the postvascular phase is detected in some cases of liver metastasis by Sonazoid-enhanced ultrasonography (US). Here, the association of the HER with histological features was investigated to clarify the cause of this characteristic imaging pattern.
SUBJECTS AND METHODS:
A total of 13 hepatic nodules obtained from 11 patients with metastatic liver cancer who underwent Sonazoid-enhanced US followed by surgical resection were analyzed. The distribution density of CD68-positive cells in the tumor rim and the nontumor area was calculated and compared between the HER-positive and HER-negative groups. The relation between the pathological features of the tumor rim and the rate of necrosis within the tumor was also investigated.
RESULTS:
In the HER-positive group (n = 8), the distribution density of CD68-positive cells was 2.9 ± 0.9, which was significantly higher than that (1.0 ± 0.3) in the HER-negative group (p < 0.05). Inflammatory cell infiltrates, including CD8-positive lymphocytes, were detected in all the HER-positive cases in the area surrounding the tumor, while fibrosis was observed in all the HER-negative cases. The necrotic area within the tumor was significantly larger in the HER-negative group.
CONCLUSION:
The HER-positive sign in liver metastases could reflect an increase in Kupffer cells in the tumor rim. The presence of the HER was associated with inflammatory cell infiltrates including CD8-positive lymphocytes surrounding the metastatic liver tumor.
AuthorsHitoshi Tochio, Masafumi Sugahara, Yukihiro Imai, Hiroshi Tei, Yoshiyuki Suginoshita, Nobuhiro Imawsaki, Ichiro Sasaki, Michio Hamada, Kazushi Minowa, Tetsuo Inokuma, Masatoshi Kudo
JournalOncology (Oncology) Vol. 89 Suppl 2 Pg. 33-41 ( 2015) ISSN: 1423-0232 [Electronic] Switzerland
PMID26584034 (Publication Type: Journal Article)
Copyright© 2015 S. Karger AG, Basel.
Chemical References
  • Contrast Media
  • Ferric Compounds
  • Oxides
  • Sonazoid
  • Iron
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media (pharmacokinetics)
  • Female
  • Ferric Compounds (pharmacokinetics)
  • Follow-Up Studies
  • Humans
  • Image Enhancement (methods)
  • Iron (pharmacokinetics)
  • Kupffer Cells (diagnostic imaging, metabolism, pathology)
  • Liver Neoplasms (diagnostic imaging, metabolism, secondary)
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Oxides (pharmacokinetics)
  • Prognosis
  • Tissue Distribution
  • Ultrasonography

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