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NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population.

Abstract
Natural resistance-associated macrophage protein (Nramp1) and the vitamin D receptor (VDR) are central components of the innate and adaptive immunity against Mycobacterium tuberculosis, and associations between susceptibility to tuberculosis and polymorphisms in the genes NRAMP and VDR have been sought in geographically diverse populations. We investigated associations of NRAMP1 and VDR gene polymorphisms with susceptibility to TB in the Venezuelan population. The results suggest the absence of any association between VDR variants FokI, ApaI, and TaqI and susceptibility to tuberculosis. In contrast, the NRAMP1 3'UTR variants were associated with susceptibility to M. tuberculosis infection, as seen in the comparisons between TST+ and TST- controls, and also with progression to TB disease, as shown in the comparisons between TB patients and TST+ controls. This study confirms the previously described association of the NRAMP1 3'UTR polymorphism with M. tuberculosis infection and disease progression.
AuthorsMercedes Fernández-Mestre, Ángel Villasmil, Howard Takiff, Zhenia Fuentes Alcalá
JournalDisease markers (Dis Markers) Vol. 2015 Pg. 860628 ( 2015) ISSN: 1875-8630 [Electronic] United States
PMID26578819 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • 3' Untranslated Regions
  • Cation Transport Proteins
  • Receptors, Calcitriol
  • VDR protein, human
  • natural resistance-associated macrophage protein 1
Topics
  • 3' Untranslated Regions
  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Cation Transport Proteins (genetics)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Restriction Fragment Length
  • Receptors, Calcitriol (genetics)
  • Tuberculosis (genetics)

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