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[Epidural administration of a morphine-adrenaline-bupivacaine mixture in obstetric anesthesia].

Abstract
Pain relieving effect of epidurally given epinephrine-morphine-bupivacaine drug combination was studied in 50 primiparous women during labour. The double-blind, randomised clinical evaluation showed that the components of our drug combination act synergistically. The total dose and the mg min-1 dose of bupivacaine was significantly less following epinephrine-morphine pretreatment than the dose required when only bupivacaine was used for pain relief. The duration of analgesic effect of separate top-up doses was also significantly prolonged when the drug combination was used. It was established that this method of obstetric pain relief uses about 30% less bupivacaine than the classical method. This means decreased drug exposure of mother and fetus alike. In addition to this the use of this drug combination provides also a long-lasting postpartum analgesia.
AuthorsJ Károvits, L Szekeres, G Juhász, Z Kincses
JournalOrvosi hetilap (Orv Hetil) Vol. 130 Issue 10 Pg. 499-502 (Mar 05 1989) ISSN: 0030-6002 [Print] Hungary
Vernacular TitleEpidurálisan adott morfin-adrenalin-bupivacain keverék a szülészeti fájdalomcsillapításban.
PMID2657547 (Publication Type: Clinical Trial, English Abstract, Journal Article, Randomized Controlled Trial, Review)
Chemical References
  • Morphine
  • Bupivacaine
  • Epinephrine
Topics
  • Anesthesia, Obstetrical (methods)
  • Bupivacaine (administration & dosage)
  • Drug Therapy, Combination
  • Epinephrine (administration & dosage)
  • Female
  • Humans
  • Infant, Newborn
  • Morphine (administration & dosage)
  • Pregnancy

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