Neonatal sepsis is an important cause of mortality and morbidity in newborns. The causative agents may be different in different units and may change in time. It was aimed to examine the microbiological agents leading to
sepsis, clinical features and
antibiotic resistances in babies with
sepsis hospitalized in our unit in a two-year period.
MATERIAL AND METHODS: The clinical features, microbiological and laboratory results, antibiotic resistance patterns and mortality rates of the newborns with
sepsis followed up in our unit between 2010 and 2011 were examined in the patient record system.
RESULTS: 351 babies diagnosed with
sepsis among 3219 patients hospitalized in the neonatal intensive care unit were included in the study. The mean gestational age was found to be 30.1±4.1 weeks, the mean
birth weight was found to be 1417.4±759.1 g and the mean hospitalization time was found to be 43.6±34.4 days. Blood cultures were found to be positive in 167 (47.6%) patients, urine cultures were found to be positive in 6 (7.1%) patients and cerebrospinal fluid cultures were found to be positive in 34 (9.6%) cases. Candida grew in 5 patients (2 patients with early-onset
sepsis and 3 patients with late-onset
sepsis). The most common cause of
sepsis was found to be staphylococci (
coagulase negative staphylococcus was found in 65 patients (51%) and Staphylococcus aureus was found in 38 patients (39%). 49.6% (n=63) of the gram positive bacteriae and 60% (n=21) of the gram negative bacteriae were resistant to
antibiotics. Six (7.1%) of the patients who were infected with these bacteriae were lost. In total 24 babies were lost because of
sepsis. The bacteriae which caused to mortality with the highest rate included E. coli,
coagulase negative staphylocicci, S. aureus and Klebsiella. Low birth weight,
mechanical ventilation and
parenteral nutrition were found to be significant risk factors in terms of mortality.
CONCLUSIONS: