Fertility Issues for Patients with Hypogonadotropic Causes of Delayed Puberty.

Abstract

Delayed puberty presenting with low gonadotropins has multiple causes. Self-limited delay (constitutional delay) is generally considered benign, but adult height and bone mineral density may be compromised, and fertility has not been studied. Functional hypogonadotropic hypogonadism due to a stressor is thought to resolve with removal of the stressor, but reproductive endocrine dysfunction can sometimes persist. Most but not all patients with idiopathic hypogonadotropic hypogonadism, a typically long-lasting condition, can achieve fertility with exogenous hormone therapy. Future studies are needed to determine fertility outcomes in self-limited delayed puberty and to more clearly define prognostic factors for fertility in functional and idiopathic hypogonadotropic hypogonadism.

• Authors: Jia Zhu, Yee-Ming Chan
• Journal: Endocrinology and metabolism clinics of North America (Endocrinol Metab Clin North Am) Vol. 44 Issue 4 Pg. 821-34 (Dec 2015) ISSN: 1558-4410 [Electronic] United States
• PMID: 26568495 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2015 Elsevier Inc. All rights reserved.

Topics

• Humans
• Hypogonadism (complications, therapy)
• Infertility (drug therapy, etiology)
• Puberty, Delayed (drug therapy, etiology)