Prevention of type 2 diabetes through lifestyle modification: is there a role for higher-protein diets?
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| Abstract |
Type 2 diabetes (T2D) incidence is increasing worldwide, driven by a rapidly changing environment and lifestyle and increasing rates of overweight and obesity. Prevention of diabetes is key and is most likely achieved through prevention of weight gain and/or successful long-term weight loss maintenance. Weight loss is readily achievable but there is considerable challenge in maintaining that weight loss over the long term. Lower-fat carbohydrate-based diets are widely used for T2D prevention. This is supported primarily by 3 successful long-term interventions, the US Diabetes Prevention Program, the Finnish Diabetes Prevention Study, and the Chinese Da Qing Study, but evidence is building in support of novel higher-protein (>20% of energy) diets for successful weight loss maintenance and prevention of T2D. Higher-protein diets have the advantage of having relatively low energy density, aiding longer-term appetite suppression, and preserving lean body mass, all central to successful weight loss and prevention of weight regain. Here, we review the carbohydrate-based intervention trials and present mechanistic evidence in support of increased dietary protein for weight loss maintenance and a possible novel role in prevention of dysglycemia and T2D.
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| Authors | Amy Y Liu, Marta P Silvestre, Sally D Poppitt |
| Journal | Advances in nutrition (Bethesda, Md.) (Adv Nutr) Vol. 6 Issue 6 Pg. 665-73 (Nov 2015) ISSN: 2156-5376 [Electronic] United States |
| PMID | 26567192 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review) |
| Copyright | © 2015 American Society for Nutrition. |
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