Abstract | AIM: MATERIALS AND METHODS: RESULTS: There was a significant increase in the severity of mucositis during the course of treatment followed by a gradual decrease in severity towards the end of radiotherapy. Comparison of C-reactive protein levels from day 0 to day 42 in the study group showed a significant increase towards the end of radiotherapy. There was a significant increase in erythrocyte sedimentation rate levels till day 14 followed by a decrease towards the end of radiotherapy whereas total leukocyte count showed a significant decrease from day 0 to day 7 followed by an increase towards the end of radiotherapy. CONCLUSION: The oral mucosa bears only a small clinical spectrum of the side-effect conveyed by chemo-radiation. Both widespread and late effects do occur, and tissues may never return to normal completely. Inflammatory serum markers like C-reactive protein, erythrocyte sedimentation rate and total leukocyte count can thus be used as an objective measure to study the complexities of radiation mucositis which is documented as one of the worst side effects of head and neck cancer therapy.
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Authors | Chethana, Pratima S Rao, Lal P Madathil, Suresh Rao, Pushparaja Shetty, Madhvika Patidar |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 9
Issue 10
Pg. ZC28-31
(Oct 2015)
ISSN: 2249-782X [Print] India |
PMID | 26557611
(Publication Type: Journal Article)
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