HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Serum Phosphorylated Neurofilament-Heavy Chain, a Potential Biomarker, is Associated With Peripheral Neuropathy in Patients With Type 2 Diabetes.

Abstract
Neurofilament (NF), one of the major axonal cytoskeletal proteins, plays a critical role in degenerative diseases in both the central and the peripheral nervous systems. The aim of this study is to explore the relationship between serum phosphorylated neurofilament-heavy chain (pNF-H) and diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes.Serum pNF-H concentrations were measured by ELISA in hospitalized patients with and without DPN (n = 118). DPN was assessed by clinical symptoms, signs, and electromyography.Compared with the non-DPN group (311.98 [189.59-634.12] pg/mL), the confirmed group (605.99 [281.17-1332.78] pg/mL) patients had the higher serum pNF-H levels (P = 0.007). DPN was significantly correlated with C-peptide (r = -0.269), total cholesterol (TC) (r = 0.185), and pNF-H (r = 0.258). Serum pNF-H levels were independently associated with DPN (P = 0.004), even after adjusting for age, sex, duration of diabetes, fasting plasma glucose, glycosylated hemoglobin A1c, TC, C-peptide, urinary albuminto/creatinine ratio, and estimated glomerular filtration rate. Compared with pNF-H quartile 1 (referent), patients in quartile 3 (odds ratio [OR], 3.977; 95% confidence interval [CI], 1.243-12.728; P = 0.021) and quartile 4 (OR, 10.488; 95% CI, 3.020-34.429; P = 0.000) had the higher risk of DPN after adjusting for the confounders.Serum pNF-H levels might be associated with the DPN, and the correlationship between serum pNF-H and DPN should be further studied.
AuthorsXiaona Qiao, Shuo Zhang, Weiwei Zhao, Hongying Ye, Yehong Yang, Zhaoyun Zhang, Qing Miao, Renming Hu, Yiming Li, Bin Lu
JournalMedicine (Medicine (Baltimore)) Vol. 94 Issue 44 Pg. e1908 (Nov 2015) ISSN: 1536-5964 [Electronic] United States
PMID26554790 (Publication Type: Journal Article)
Chemical References
  • Biomarkers
  • Glycated Hemoglobin A
Topics
  • Aged
  • Biomarkers (blood)
  • Diabetes Mellitus, Type 2 (blood, complications)
  • Diabetic Neuropathies (blood, etiology)
  • Disease Progression
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Glycated Hemoglobin (metabolism)
  • Humans
  • Intermediate Filaments (metabolism)
  • Male
  • Middle Aged
  • Phosphorylation
  • Pilot Projects
  • Retrospective Studies

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: