Abstract | BACKGROUND: Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available. PATIENTS AND METHODS: To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 patients with suspected allergy to carmine red was subjected to a single-blind placebo-controlled oral challenge test with carmine red. RESULTS: Five patients developed clinical symptoms during the placebo-controlled oral challenge. As a result, the overall frequency of clinical carmine allergy is estimated to be 0.7% in general dermatology patients studied for food-associated symptoms. CONCLUSIONS: Oral challenge test provides a valuable in vivo tool to better inform patients with positive skin prick tests to additives to avoid false allergy diets.
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Authors | J Liippo, K Lammintausta |
Journal | European annals of allergy and clinical immunology
(Eur Ann Allergy Clin Immunol)
Vol. 47
Issue 6
Pg. 206-10
(Nov 2015)
ISSN: 1764-1489 [Print] Italy |
PMID | 26549338
(Publication Type: Journal Article)
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Chemical References |
- Food Coloring Agents
- Carmine
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Topics |
- Administration, Oral
- Adult
- Aged
- Carmine
(administration & dosage, adverse effects)
- Female
- Finland
(epidemiology)
- Food Coloring Agents
(administration & dosage, adverse effects)
- Food Hypersensitivity
(diagnosis, epidemiology, immunology)
- Humans
- Intradermal Tests
- Male
- Middle Aged
- Predictive Value of Tests
- Retrospective Studies
- Risk Factors
- Single-Blind Method
- Young Adult
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