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An oral challenge test with carmine red (E120) in skin prick test positive patients.

AbstractBACKGROUND:
Positive skin prick test reactions to carmine red (E120) occur in approximately 3% of the patients studied for food allergy. Carmine ingestion associated systemic symptoms are occasionally suspected, but sufficient information of proven carmine allergy is not available.
PATIENTS AND METHODS:
To analyse carmine related symptoms in skin prick test positive patients a cohort of 23 patients with suspected allergy to carmine red was subjected to a single-blind placebo-controlled oral challenge test with carmine red.
RESULTS:
Five patients developed clinical symptoms during the placebo-controlled oral challenge. As a result, the overall frequency of clinical carmine allergy is estimated to be 0.7% in general dermatology patients studied for food-associated symptoms.
CONCLUSIONS:
Oral challenge test provides a valuable in vivo tool to better inform patients with positive skin prick tests to additives to avoid false allergy diets.
AuthorsJ Liippo, K Lammintausta
JournalEuropean annals of allergy and clinical immunology (Eur Ann Allergy Clin Immunol) Vol. 47 Issue 6 Pg. 206-10 (Nov 2015) ISSN: 1764-1489 [Print] Italy
PMID26549338 (Publication Type: Journal Article)
Chemical References
  • Food Coloring Agents
  • Carmine
Topics
  • Administration, Oral
  • Adult
  • Aged
  • Carmine (administration & dosage, adverse effects)
  • Female
  • Finland (epidemiology)
  • Food Coloring Agents (administration & dosage, adverse effects)
  • Food Hypersensitivity (diagnosis, epidemiology, immunology)
  • Humans
  • Intradermal Tests
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Retrospective Studies
  • Risk Factors
  • Single-Blind Method
  • Young Adult

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