Abstract | PURPOSE: To evaluate the effectiveness of a hyperosmolar medication in corneal edema. METHODS: This was a prospective randomized study, performed in patients with post-operative corneal edema. Two groups were created: group 1 treated with hypertonic eye drops of 5% sodium chloride with 0.15% sodium hyaluronate in addition to the usual post-operative treatment for 1 month; group 2 without treatment for edema. Visual acuity, pachymetry and corneal density were measured at 1 day, 1 week, 1 month, 3 months and 6 months following surgery. RESULTS: Forty-four patients were included in group 1 and 42 in group 2. Visual acuity was significantly better in group 1 than in group 2 at 7 days (0.84 logMAR vs 1.55 logMAR, P=0.019 CI 95% [-1.298;-0.128]) and was no longer different at one month, three and six months. Pachymetry decreased significantly in 7 days in group 1 (decrease of 17%, P=0.04, CI 95% [1.987; 258.305]), compared to group 2 (P=0.8, CI 95% [-132.9; 161.8]), but the difference between the 2 groups was not statistically significant (P=0.11, CI 95% [-16; 19.1]). Corneal density was also not significantly different between the two groups. CONCLUSION: Five percent sodium chloride hypertonic eye drops show a statistically significant reduction in post-operative corneal edema as shown by the improvement in visual acuity at one week and the downward trend in pachymetry.
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Authors | G Ho Wang Yin, M Sampo, S Soare, L Hoffart |
Journal | Journal francais d'ophtalmologie
(J Fr Ophtalmol)
Vol. 38
Issue 10
Pg. 967-73
(Dec 2015)
ISSN: 1773-0597 [Electronic] France |
Vernacular Title | Acuité visuelle, pachymétrie et densité cornéenne après traitement par solution hyperosmolaire au chlorure de sodium 5 % dans l'œdème cornéen postopératoire. |
PMID | 26547229
(Publication Type: Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2015 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Saline Solution, Hypertonic
- Hyaluronic Acid
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Topics |
- Aged
- Aged, 80 and over
- Corneal Edema
(drug therapy, etiology, pathology)
- Corneal Pachymetry
- Densitometry
- Drug Therapy, Combination
- Female
- Humans
- Hyaluronic Acid
(therapeutic use)
- Male
- Middle Aged
- Ophthalmologic Surgical Procedures
- Postoperative Complications
(drug therapy, etiology, pathology)
- Prospective Studies
- Saline Solution, Hypertonic
(therapeutic use)
- Treatment Outcome
- Visual Acuity
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