The therapeutic effect of human recombinant macrophage colony stimulating factor (CSF-1) in experimental murine metastatic melanoma.

Abstract

This paper investigates the effect of recombinant human macrophage colony-stimulating factor (CSF-1) on the interaction between mononuclear phagocytes and the metastatic murine melanoma, B16/B16. CSF-1 had no effect on the ability of primary or bone marrow-derived macrophages to kill B16 cells in vitro, nor on their activation for cytotoxicity by gamma interferon plus LPS. However, when administered in vivo, CSF-1 increased the number of monocytes and peritoneal cells in tumor-bearing animals, and led to a significant reduction in the appearance of pulmonary and extra-pulmonary metastatic lesions derived from primary B16 tumors. The results suggest a therapeutic potential for CSF-1 in the treatment of malignancy.

• Authors: D A Hume, R E Donahue, I J Fidler
• Journal: Lymphokine research (Lymphokine Res) Vol. 8 Issue 1 Pg. 69-77 ( 1989) ISSN: 0277-6766 [Print] United States
• PMID: 2654493 (Publication Type: Journal Article)

Chemical References

• Colony-Stimulating Factors
• Growth Substances
• Recombinant Proteins
• Granulocyte-Macrophage Colony-Stimulating Factor

Topics

• Animals
• Body Weight (drug effects)
• Colony-Stimulating Factors (therapeutic use)
• Female
• Granulocyte-Macrophage Colony-Stimulating Factor
• Growth Substances (therapeutic use)
• Melanoma, Experimental (drug therapy, mortality)
• Mice
• Mice, Inbred C57BL
• Neoplasm Metastasis
• Recombinant Proteins (therapeutic use)