Retrospective analysis on safety and efficacy of everolimus in treatment of metastatic renal cancer patients receiving dialysis.

Abstract

AIMS:

This retrospective study aimed to investigate safety and efficacy of everolimus in patients with metastatic renal cell carcinoma (mRCC) and end-stage renal disease requiring dialysis.

PATIENTS & METHODS:

From November 2009 to December 2012, 11 mRCC patients undergoing dialysis were treated with everolimus after failure of anti-VEGF therapy at six Italian institutions. Patient characteristics, safety and outcomes were collected.

RESULTS:

Progression-free survival and overall survival were determined using the Kaplan-Meier method. Median progression-free survival and overall survival were 9.01 and 15.7 months, respectively. No unexpected adverse events were reported.

CONCLUSION:

Everolimus appears to be safe in mRCC patients with renal impairment or end-stage renal disease requiring dialysis. Larger prospective studies are required to confirm these findings.

• Authors: Annalisa Guida, Cristina Masini, Michele Milella, Giuseppe Di Lorenzo, Matteo Santoni, Veronica Prati, Camillo Porta, Laura Cosmai, Donatella Donati, Cinzia del Giovane, Pasquale Mighali, Roberto Sabbatini
• Journal: Future oncology (London, England) (Future Oncol) Vol. 11 Issue 23 Pg. 3159-66 ( 2015) ISSN: 1744-8301 [Electronic] England
• PMID: 26544922 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Protein Kinase Inhibitors
• Everolimus

Topics

• Aged
• Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
• Carcinoma, Renal Cell (mortality, pathology, therapy)
• Combined Modality Therapy
• Everolimus (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Kaplan-Meier Estimate
• Kidney Neoplasms (mortality, pathology, therapy)
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Protein Kinase Inhibitors (administration & dosage, adverse effects, therapeutic use)
• Renal Dialysis (methods)
• Retrospective Studies
• Treatment Outcome