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[5-Fluorouracil, adriamycin, and mitomycin C (FAM) combination chemotherapy in adenocarcinoma of the parotid gland].

Abstract
An adenocarcinoma of the parotid gland is a rare tumor and little is known about the efficacy of chemotherapy as a method of treatment. Four patients with a metastatic, or recurrent adenocarcinoma of the parotid gland were treated with a combination chemotherapy consisting of 5-fluorouracil, adriamycin, and mitomycin C (FAM): 5-fluorouracil 330-500 mg/m2, d1-3, q3w or tegafur 400-600 mg/m2 p.o. adriamycin 30-40 mg/m2 q3w, and mitomycin C 3-10 mg/m2, q1-2w. One patient with a lung metastasis showed a good partial response lasting for 19 months and another patient who was resistant to CDDP plus the adriamycin combination, having a lymph node, bone, and bone marrow metastases, had a partial response lasting for 31 months. Results have indicated that adriamycin is one of the effective therapeutic drugs and that FAM combination chemotherapy can provide some efficacy against a parotid cancer.
AuthorsK Inoue, N Horikoshi, T Mukaiyama, M Ogawa, Y Kuraishi
JournalGan no rinsho. Japan journal of cancer clinics (Gan No Rinsho) Vol. 35 Issue 4 Pg. 481-5 (Mar 1989) ISSN: 0021-4949 [Print] Japan
PMID2654442 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Mitomycins
  • Mitomycin
  • Doxorubicin
  • Fluorouracil
Topics
  • Adenocarcinoma (drug therapy, secondary)
  • Adult
  • Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
  • Bone Neoplasms (drug therapy, secondary)
  • Doxorubicin (administration & dosage)
  • Drug Administration Schedule
  • Drug Evaluation
  • Female
  • Fluorouracil (administration & dosage)
  • Humans
  • Lung Neoplasms (drug therapy, secondary)
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mitomycin
  • Mitomycins (administration & dosage)
  • Neoplasm Recurrence, Local (drug therapy)
  • Parotid Neoplasms (drug therapy, pathology)
  • Remission Induction

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