Abstract |
An adenocarcinoma of the parotid gland is a rare tumor and little is known about the efficacy of chemotherapy as a method of treatment. Four patients with a metastatic, or recurrent adenocarcinoma of the parotid gland were treated with a combination chemotherapy consisting of 5-fluorouracil, adriamycin, and mitomycin C (FAM): 5-fluorouracil 330-500 mg/m2, d1-3, q3w or tegafur 400-600 mg/m2 p.o. adriamycin 30-40 mg/m2 q3w, and mitomycin C 3-10 mg/m2, q1-2w. One patient with a lung metastasis showed a good partial response lasting for 19 months and another patient who was resistant to CDDP plus the adriamycin combination, having a lymph node, bone, and bone marrow metastases, had a partial response lasting for 31 months. Results have indicated that adriamycin is one of the effective therapeutic drugs and that FAM combination chemotherapy can provide some efficacy against a parotid cancer.
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Authors | K Inoue, N Horikoshi, T Mukaiyama, M Ogawa, Y Kuraishi |
Journal | Gan no rinsho. Japan journal of cancer clinics
(Gan No Rinsho)
Vol. 35
Issue 4
Pg. 481-5
(Mar 1989)
ISSN: 0021-4949 [Print] Japan |
PMID | 2654442
(Publication Type: Case Reports, English Abstract, Journal Article, Review)
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Chemical References |
- Mitomycins
- Mitomycin
- Doxorubicin
- Fluorouracil
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Topics |
- Adenocarcinoma
(drug therapy, secondary)
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bone Neoplasms
(drug therapy, secondary)
- Doxorubicin
(administration & dosage)
- Drug Administration Schedule
- Drug Evaluation
- Female
- Fluorouracil
(administration & dosage)
- Humans
- Lung Neoplasms
(drug therapy, secondary)
- Lymphatic Metastasis
- Male
- Middle Aged
- Mitomycin
- Mitomycins
(administration & dosage)
- Neoplasm Recurrence, Local
(drug therapy)
- Parotid Neoplasms
(drug therapy, pathology)
- Remission Induction
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