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Effectiveness of lithium in schizophrenia: do we really have an answer?

Abstract
The authors review all double-blind studies assessing the efficacy of lithium treatment in schizophrenia. They conclude that active affective symptoms, previous affective episodes, and a family history of affective disorder may predict a favorable response to lithium. However, methodological problems in past studies (e.g., small samples, lack of strict diagnostic criteria) suggest that further clinical trials are warranted.
AuthorsN Atre-Vaidya, M A Taylor
JournalThe Journal of clinical psychiatry (J Clin Psychiatry) Vol. 50 Issue 5 Pg. 170-3 (May 1989) ISSN: 0160-6689 [Print] United States
PMID2654127 (Publication Type: Clinical Trial, Journal Article, Review)
Chemical References
  • Lithium
Topics
  • Chronic Disease
  • Clinical Trials as Topic
  • Double-Blind Method
  • Humans
  • Lithium (therapeutic use)
  • Mood Disorders (complications, genetics)
  • Probability
  • Research Design (standards)
  • Schizophrenia (complications, drug therapy)

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