HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Eldecalcitol prevents endothelial dysfunction in postmenopausal osteoporosis model rats.

Abstract
Postmenopausal women have high incidence of cardiovascular events as estrogen deficiency can cause endothelial dysfunction. Vitamin D is reported to be beneficial on endothelial function, but it remains controversial whether vitamin D is effective for endothelial dysfunction under the treatment for osteoporosis in postmenopausal women. The aim of this study was to evaluate the endothelial protective effect of eldecalcitol (ELD) in ovariectomized (OVX) rats. ELD (20  ng/kg) was orally administrated five times a week for 4 weeks from 1 day after surgery. After that, flow-mediated dilation (FMD) as an indicator of endothelial function was measured by high-resolution ultrasound in the femoral artery of living rats. ELD ameliorated the reduction of FMD in OVX rats. ELD inhibited the increase in NOX4, nitrotyrosine, and p65 and the decrease in dimer/monomer ratio of nitric oxide synthase in OVX rat femoral arteries. ELD also prevented the decrease in peroxisome proliferator-activated receptor gamma (PPARγ) in femoral arteries and cultured endothelial cells. Although PPARγ is known to inhibit osteoblastogenesis, ELD understandably increased bone mineral density of OVX rats without increase in PPARγ in bone marrow. These results suggest that ELD prevented the deterioration of endothelial function under condition of preventing bone loss in OVX rats. This endothelial protective effect of ELD might be exerted through improvement of endothelial nitric oxide synthase uncoupling, which is mediated by an antioxidative effect through normalization of vascular PPARγ/NF-κB signaling.
AuthorsKenichi Serizawa, Kenji Yogo, Yoshihito Tashiro, Satoshi Takeda, Ryohei Kawasaki, Ken Aizawa, Koichi Endo
JournalThe Journal of endocrinology (J Endocrinol) Vol. 228 Issue 2 Pg. 75-84 (Feb 2016) ISSN: 1479-6805 [Electronic] England
PMID26537128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Copyright© 2016 Society for Endocrinology.
Chemical References
  • PPAR gamma
  • Vitamin D
  • Nitric Oxide Synthase Type III
  • eldecalcitol
Topics
  • Animals
  • Bone Density (drug effects)
  • Bone Marrow (chemistry)
  • Cells, Cultured
  • Dimerization
  • Endothelium, Vascular (chemistry, physiopathology)
  • Female
  • Femoral Artery (chemistry, diagnostic imaging, physiopathology)
  • Humans
  • Nitric Oxide Synthase Type III (analysis, chemistry, metabolism)
  • Osteoporosis, Postmenopausal (physiopathology, prevention & control)
  • Ovariectomy
  • PPAR gamma (analysis)
  • Postmenopause
  • Rats
  • Rats, Sprague-Dawley
  • Ultrasonography
  • Vasodilation (drug effects)
  • Vitamin D (administration & dosage, analogs & derivatives)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: