Abstract |
To examine the clinical and parasitologic efficacy of quinine, we studied 34 children (7 months-13 years old) with severe or moderately severe Plasmodium falciparum infections. Quinine 10 mg/kg every 8 hr for 3 days was administered, initially by intravenous infusion of quinine formate followed by oral quinine dihydrochloride when tolerated. Thirty-three of the 34 patients were clinically well and had negative malaria smears 7 days after the initiation of therapy; 1 child, who presented in coma, died 29 hr after enrollment. The mean fever clearance time was 44.1 hr, and the mean parasite clearance time was 59.6 hr. A mean peak quinine level of 9.7 ppm was attained after the second dose of quinine, and the minimum concentration was maintained at 5-7 ppm during the 2nd and 3rd hospital days. In vitro testing was conducted with parasites from 10 patients: 9 isolates were resistant to chloroquine, and inhibition of schizont development with quinine occurred at a concentration of 8-32 pmol/well.
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Authors | A E Greenberg, P Nguyen-Dinh, F Davachi, B Yemvula, N Malanda, M Nzeza, S B Williams, J F de Zwart, M Nzeza |
Journal | The American journal of tropical medicine and hygiene
(Am J Trop Med Hyg)
Vol. 40
Issue 4
Pg. 360-4
(Apr 1989)
ISSN: 0002-9637 [Print] United States |
PMID | 2653061
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Adolescent
- Animals
- Blood Transfusion
- Child
- Child, Preschool
- Democratic Republic of the Congo
- Female
- Fever
(drug therapy)
- Humans
- Infant
- Infusions, Intravenous
- Malaria
(drug therapy, epidemiology, therapy)
- Male
- Plasmodium falciparum
(drug effects)
- Quinine
(pharmacokinetics, therapeutic use)
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