Role of B cells in presentation of autoantigens to CD4(+) T cells in patients with autoimmune thyroiditis.

Abstract

The antigen-presenting activity of B cells and expression of molecules involved in antigen presentation by B cells have been studied in patients with autoimmune thyroiditis (AIT). The disease is characterized by enhanced expression of the costimulatory molecule CD80 in naive B cells (CD19(+)CD27(-) cells) both ex vivo and under the conditions of polyclonal cell activation in a culture. Under in vitro conditions, antigen-loaded B cells have been shown to be capable of inducing proliferation of autologous CD4(+) cells, in particular, proliferation of autospecific T cells in patients with AIT. Given that an intense infiltration of thyroid tissue by B cells is a typical sign of AIT, the antigen-presenting activity of B cells appears to contribute to this pathology.

• Authors: E M Kuklina, E N Smirnova, I V Nekrasova, T S Balashova
• Journal: Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections (Dokl Biol Sci) Vol. 464 Pg. 263-6 ( 2015) ISSN: 1608-3105 [Electronic] United States
• PMID: 26530073 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Autoantigens

Topics

• Adult
• Antigen Presentation
• Autoantigens (immunology)
• B-Lymphocytes (immunology)
• CD4-Positive T-Lymphocytes (immunology)
• Case-Control Studies
• Female
• Humans
• Male
• Thyroiditis, Autoimmune (immunology)