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Evaluation of serum β-hCG and PAPP-A levels in pregnant women at risk of developing preeclampsia.

AbstractBACKGROUND AND AIM:
Preeclampsia remains a major problem of modern obstetrics with insufficiently elucidated etiology; early detection would diminish maternal and fetal mortality and morbidity. The aim of this study was to determine the serum values of β-hCG in the first and second trimesters of pregnancy and PAPP-A values in the first trimester of pregnancy in pregnant women with risk factors for preeclampsia, in order to evaluate their relevance in the prediction of this disorder.
MATERIAL AND METHODS:
We performed a prospective longitudinal study on 120 pregnant women divided into two groups according to the evolution of pregnancy: group I - 26 pregnant women who developed preeclampsia and group II - 94 pregnant women who did not develop preeclampsia and had a physiological evolution of pregnancy.
RESULTS:
Our results indicate the association between high β-hCG levels in the first and second trimesters of pregnancy and the development of PE, β-hCG having the highest predictive power in the second trimester. We also obtained a positive association between low serum levels in PAPP-A in the first trimester and onset of PE. The predictive power of conjugated β-hCG and PAPP-A values in the first trimester of pregnancy was better that any other marker analyzed separately.
CONCLUSIONS:
Increased β-hCG levels in the first and second trimesters of pregnancy and low PAPP-A levels in the second trimester of pregnancy are associated with a higher risk for PE, the study providing only a modest efficiency of the prediction capacity.
AuthorsMihaela Daniela Oancea, Nicolae Costin, Daria Maria Pop, Razvan Ciortea, Dan Mihu
JournalClujul medical (1957) (Clujul Med) Vol. 86 Issue 4 Pg. 347-51 ( 2013) ISSN: 1222-2119 [Print] Romania
PMID26527976 (Publication Type: Journal Article)

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