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[A tribute to the memory of the illustrious maestro and academic Dr. Rafael Méndez Martínez, pioneer in the pharmacological studies of digitalis and digitalis glycosides].

Abstract
Since the end of the XVIII century, digitalis glycosides were employed in heart failure. They were considered initially as diuretics and later as cardiotonic agents or as positive inotropics. At the present time there are varied groups of positive inotropic agents, which have a beneficial action on the failing human myocardium. For example, the beta adrenergics, the phosphodiesterase III inhibitors such as milrinone, or the sensibilizers of myocardial proteins to Ca++ such as levosimendan and omecamtiv mecarbil. However, following the opinion of distinguished cardiologists, in the case of heart failure associated to atrial fibrillation, digitalis cannot be substituted.
AuthorsAlfredo de Micheli Serra, Gustavo Pastelín Hernández
JournalGaceta medica de Mexico (Gac Med Mex) 2015 Sep-Oct Vol. 151 Issue 5 Pg. 660-5 ISSN: 0016-3813 [Print] Mexico
Vernacular TitleBreve historia de la digital y los digitálicos. Homenaje a la memoria del ilustre maestro y académico Dr. Rafael Méndez Martínez, pionero de los estudios farmacológicos sobre la digital y los glucósidos digitálicos.
PMID26526481 (Publication Type: English Abstract, Historical Article, Journal Article)
Chemical References
  • Digitalis Glycosides
Topics
  • Digitalis
  • Digitalis Glycosides (history)
  • History, 16th Century
  • History, 18th Century
  • History, 19th Century
  • Humans
  • Mexico
  • Pharmacology (history)

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