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Proactive Semantic Interference is Associated with Total and Regional Abnormal Amyloid Load in Non-Demented Community-Dwelling Elders: A Preliminary Study.

AbstractOBJECTIVE:
To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders.
METHODS:
27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging.
RESULTS:
High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed.
CONCLUSIONS:
In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
AuthorsDavid A Loewenstein, Maria T Greig, Rosie Curiel, Rosemarie Rodriguez, Meredith Wicklund, Warren W Barker, Jacqueline Hidalgo, Marian Rosado, Ranjan Duara
JournalThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry (Am J Geriatr Psychiatry) Vol. 23 Issue 12 Pg. 1276-1279 (Dec 2015) ISSN: 1545-7214 [Electronic] England
PMID26525994 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Amyloid
Topics
  • Aged
  • Aged, 80 and over
  • Amyloid (metabolism)
  • Brain (diagnostic imaging, metabolism)
  • Brain Mapping (methods)
  • Female
  • Geriatric Assessment (statistics & numerical data)
  • Humans
  • Male
  • Positron-Emission Tomography
  • Residence Characteristics
  • Semantics

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