Abstract | OBJECTIVE: To evaluate the relationship between susceptibility to proactive semantic interference (PSI) and retroactive semantic interference (RSI) and brain amyloid load in non-demented elders. METHODS: 27 participants (11 cognitively normal [CN] with subjective memory complaints, 8 CN without memory complaints, and 8 with mild cognitive impairment [MCI]) underwent complete neurological and neuropsychological evaluations. Participants also received the Semantic Interference Test (SIT) and AV-45 amyloid PET imaging. RESULTS: High levels of association were present between total amyloid load, regional amyloid levels, and the PSI measure (in the entire sample and a subsample excluding MCI subjects). RSI and other memory measures showed much weaker associations or no associations with total and regional amyloid load. No associations between amyloid levels and non-memory performance were observed. CONCLUSIONS: In non-demented individuals, vulnerability to PSI was highly associated with total and regional beta-amyloid load and may be an early cognitive marker of brain pathology.
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Authors | David A Loewenstein, Maria T Greig, Rosie Curiel, Rosemarie Rodriguez, Meredith Wicklund, Warren W Barker, Jacqueline Hidalgo, Marian Rosado, Ranjan Duara |
Journal | The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
(Am J Geriatr Psychiatry)
Vol. 23
Issue 12
Pg. 1276-1279
(Dec 2015)
ISSN: 1545-7214 [Electronic] England |
PMID | 26525994
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Amyloid
(metabolism)
- Brain
(diagnostic imaging, metabolism)
- Brain Mapping
(methods)
- Female
- Geriatric Assessment
(statistics & numerical data)
- Humans
- Male
- Positron-Emission Tomography
- Residence Characteristics
- Semantics
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