Chemotherapy Induced Acute Pericarditis in a Child.

Abstract

A9 years boy diagnosed with nasopharyngeal carcinoma was started on chemotherapy protocol including 5-fluorouracil. After 90 hours of 5-fluorouracil infusion, he developed severe retrosternal chest pain. Electrocardiography showed signs of acute pericarditis and was managed with ibuprofen and 5-fluorouracil was discontinued. The 5-fluorouracil rarely causes cardiac complications such as angina pectoris and pericarditis in adult patients. We report acute myopericarditis in a child caused by 5-fluorouracil, which is a very rare complication of 5-fluorouracil in pediatric age group.

• Authors: Muhammad Arif Khan, Abdul Rahman, S Almoukirish, Shehla Jadoon, Tarek S Momenah
• Journal: Journal of the College of Physicians and Surgeons--Pakistan : JCPSP (J Coll Physicians Surg Pak) Vol. 25 Suppl 2 Pg. S81-3 (Oct 2015) ISSN: 1681-7168 [Electronic] Pakistan
• PMID: 26522211 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Fluorouracil
• Ibuprofen

Topics

• Acute Disease
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Biopsy
• Carcinoma
• Chest Pain (diagnosis, drug therapy, etiology)
• Child
• Electrocardiography
• Fluorouracil (administration & dosage, adverse effects)
• Humans
• Ibuprofen (therapeutic use)
• Infusion Pumps
• Magnetic Resonance Imaging
• Male
• Nasopharyngeal Carcinoma
• Nasopharyngeal Neoplasms (diagnosis, drug therapy)
• Pericarditis (chemically induced, drug therapy)
• Tachycardia, Sinus
• Treatment Outcome