NxStage dialysis system-associated thrombocytopenia: a report of two cases.

Abstract

Thrombocytopenia in hemodialysis patients has recently been reported to be commonly caused by electron-beam sterilization of dialysis filters. We report the occurrence of thrombocytopenia in the first two patients of a newly established home hemodialysis program. The 2 patients switched from conventional hemodialysis using polysulfone electron-beam sterilized dialyzers to a NxStage system, which uses gamma sterilized polyehersulfone dialyzers incorporated into a drop-in cartridge. The thrombocytopenia resolved after return to conventional dialysis in both patients and recurred upon rechallenge in the patient who opted to retry NxStage. This is the first report of thrombocytopenia with the NxStage system according to the authors’ knowledge. Dialysis-associated thrombocytopenia pathophysiology and clinical significance are not well understood and warrant additional investigations.

• Authors: Mohamed Sekkarie, Michelle Waldron, Texas Reynolds
• Journal: Clinical nephrology (Clin Nephrol) Vol. 85 Issue 1 Pg. 53-6 (Jan 2016) ISSN: 0301-0430 [Print] Germany
• PMID: 26521886 (Publication Type: Case Reports, Journal Article)

Chemical References

• Polymers
• Sulfones
• polysulfone P 1700

Topics

• Hemodialysis, Home (adverse effects, instrumentation)
• Humans
• Kidneys, Artificial (adverse effects)
• Male
• Middle Aged
• Polymers
• Renal Insufficiency, Chronic (therapy)
• Sulfones
• Thrombocytopenia (etiology)