Multiple Pituitary Hormone Deficiency, Empty Sella and Ectopic Neurohypophysis in Turner Syndrome.

Abstract

BACKGROUND:

Multiple pituitary hormone deficiency and Turner syndrome have overlapping features in peripubertal girls and is a diagnostic challenge.

CASE CHARACTERISTICS:

16-year-old girl having Turner phenotype undergoing evaluation for severe short stature and pubertal arrest.

OBSERVATION:

45,X karyotype, and multiple pituitary hormone deficiency with empty sella.

INTERVENTION:

Levothyroxine, growth hormone and ethinyl-estradiol replacement resulted in 11 cm height gain with attainment of puberty over 2 years.

MESSAGE:

Patients of Turner syndrome with height <3rd percentile (Turner specific charts) warrant additional pathology evaluation.

• Authors: Deep Dutta, Chitra Selvan, Satinath Mukhopadhyay
• Journal: Indian pediatrics (Indian Pediatr) Vol. 52 Issue 9 Pg. 803-4 (Sep 2015) ISSN: 0974-7559 [Electronic] India
• PMID: 26519720 (Publication Type: Case Reports, Journal Article)

Chemical References

• Gonadotropins
• Growth Hormone

Topics

• Adolescent
• Empty Sella Syndrome
• Female
• Gonadotropins (deficiency)
• Growth Hormone (deficiency)
• Humans
• Hypothyroidism
• Turner Syndrome