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Infliximab-associated fulminant hepatic failure in ulcerative colitis: a case report.

AbstractINTRODUCTION:
Infliximab, an antibody against tumor necrosis factor alpha, is used to treat inflammatory bowel disease and has well-established efficacy and proven safety. Complications of this treatment are related to immunosuppression and include higher risk of serious infections and malignant neoplasia. Although extremely rare, fulminant liver damage related to infliximab therapy has been reported.
CASE PRESENTATION:
We present the case of a 38-year-old Afro-Brazilian woman with refractory ulcerative colitis who was started on infliximab. She had no previous history of liver disease, alcohol abuse, or infection. After the fifth dose of the medication, drug-induced liver injury was diagnosed. Treatment was discontinued but our patient's condition was aggravated by severe cholestasis and grade III/IV encephalopathy, requiring liver transplantation.
CONCLUSION:
Drug-induced liver injury is an uncommon complication of infliximab. Current consensus recommends screening for liver dysfunction prior to and during therapy. This case emphasizes the need for vigilance and highlights a rare and potentially lethal complication.
AuthorsRogerio Serafim Parra, Marley Ribeiro Feitosa, Vanessa Foresto Machado, Leandra Naira Zambelli Ramalho, Jose Joaquim Ribeiro da Rocha, Omar Feres
JournalJournal of medical case reports (J Med Case Rep) Vol. 9 Pg. 249 (Oct 30 2015) ISSN: 1752-1947 [Electronic] England
PMID26518665 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Gastrointestinal Agents
  • Tumor Necrosis Factor-alpha
  • Infliximab
Topics
  • Adult
  • Chemical and Drug Induced Liver Injury (pathology, therapy)
  • Colitis, Ulcerative (drug therapy)
  • Female
  • Gastrointestinal Agents (administration & dosage, adverse effects)
  • Humans
  • Infliximab (administration & dosage, adverse effects)
  • Liver Failure, Acute (chemically induced, therapy)
  • Liver Transplantation
  • Treatment Outcome
  • Tumor Necrosis Factor-alpha (antagonists & inhibitors)

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