[Clinical significance of intrinsic sympathomimetic activity of the beta blocker carteolol. II: Comparative studies of carteolol and pindolol in patients with bradycardia].
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| Abstract |
Completing previous studies in patients with sinus bradycardia (Med. Klin. 82 [1987], 647-650) we compared metoprolol with carteolol and pindolol, pindolol with carteolol, no treatment with carteolol (in two groups) in five series of the paired comparisons of Holter-ECG each. With change from metoprolol to carteolol or pindolol (dose ratio 10:1) lowest heart rate on Holter-ECG increased by 28 or 29% without change of exercise heart rate. Direct comparison of pindolol and carteolol revealed a very similar heart rate profile, indicating equipotent beta blockade and ISA. In patients with previous beta blocker induced bradycardia, carteolol did not change a normal resting heart rate off treatment. However, in patients with spontaneous sinus bradycardia carteolol increased lowest heart rate (+14%, due to overriding ISA) and lowered exercise heart rate (-15%, due to overriding beta blockade). A beta blocker induced sinus bradycardia consistently improved with change of treatment to carteolol and pindolol. With caution carteolol and pindolol may also be used despite spontaneous sinus bradycardia.
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| Authors | G Lohmöller, M Middeke, C Mrowka, C Pötzl, W Renner, W Zoller |
| Journal | Medizinische Klinik (Munich, Germany : 1983) (Med Klin (Munich)) Vol. 84 Issue 2 Pg. 81-5 (Feb 15 1989) ISSN: 0723-5003 [Print] Germany |
| Vernacular Title | Klinische Bedeutung der ISA des Betablockers Carteolol. Teil II: Vergleichende Untersuchungen von Carteolol und Pindolol bei Patienten mit Bradykardie. |
| PMID | 2651861 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article) |
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