Abstract | CONTEXT: OBJECTIVE: DESIGN AND PATIENTS: First, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin responses to a standardized mixed liquid meal (SMLM) were compared between subjects with good WL (G-WL, n = 32) or P-WLM (n = 22). Second, we evaluated food intake (FI) following blockade of gut hormonal secretion in G-WL (n = 23) or P-WLM (n = 19) subjects. Finally, the impact of dietary-induced WL on the hormonal response in subjects with P-WLM (n = 14) was assessed. SETTING: This study was undertaken in a tertiary hospital. MAIN OUTCOME MEASURES: RESULTS: P-WLM associated a blunted GLP-1 (P = .044) and PYY (P = .001) responses and lesser suppression of ghrelin (P = .032) following the SMLM challenge. On saline day, FI in the G-WL (393 ± 143 kcal) group was less than in the P-WLM (519 ± 143 Kcal; P = .014) group. Octreotide injection resulted in enlarged FI in both groups (G-WL: 579 ± 248 kcal, P = .014; P-WLM: 798 ± 284 Kcal, P = .036), but the difference in FI between groups remained (P < .001). In subjects with P-WLM, dietary-induced WL resulted in larger ghrelin suppression (P = .046), but no change in the GLP-1 or PYY responses. CONCLUSION: Our data show gastrointestinal hormones play a role in the control of FI following RYGB, but do not support that changes in GLP-1, PYY, or ghrelin play a major role as determinants of P-WLM after this type of surgery.
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Authors | Ana de Hollanda, Gregori Casals, Salvadora Delgado, Amanda Jiménez, Judith Viaplana, Antonio M Lacy, Josep Vidal |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 100
Issue 12
Pg. 4677-84
(Dec 2015)
ISSN: 1945-7197 [Electronic] United States |
PMID | 26505823
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gastrointestinal Hormones
- Ghrelin
- Peptide YY
- Glucagon-Like Peptide 1
- Octreotide
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Topics |
- Adult
- Case-Control Studies
- Cohort Studies
- Diet
- Diet, Reducing
- Eating
- Female
- Gastric Bypass
- Gastrointestinal Hormones
(blood)
- Ghrelin
(blood)
- Glucagon-Like Peptide 1
(blood)
- Humans
- Male
- Middle Aged
- Obesity, Morbid
(diet therapy, metabolism, surgery)
- Octreotide
(pharmacology)
- Peptide YY
(blood)
- Treatment Outcome
- Weight Loss
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