Acute S100B in serum is associated with cognitive symptoms and memory performance 4 months after paediatric mild traumatic brain injury.

Abstract

OBJECTIVE:

This study explored whether acute serum marker S100B is related with post-concussive symptoms (PCS) and neuropsychological performance 4 months after paediatric mild traumatic brain injury (mTBI).

RESEARCH DESIGN AND METHODS:

This prospective short-term longitudinal study investigated children (aged 6-16 years) with mTBI (n = 36, 16 males) and children with orthopaedic injuries (OI, n = 27, 18 males) as a control group. S100B in serum was measured during the acute phase and was correlated with parent-rated PCS and neuropsychological performance 4 months after the injury.

MAIN OUTCOMES AND RESULTS:

The results revealed no between-group difference regarding acute S100B serum concentration. In children after mTBI, group-specific significant Spearman correlations were found between S100B and post-acute cognitive PCS (r = 0.54, p = 0.001) as well as S100B and verbal memory performance (r = -0.47, p = 0.006). In children after OI, there were insignificant positive relations between S100B and post-acute somatic PCS. In addition, insignificant positive correlations were found between neuropsychological outcome and S100B in children after OI.

CONCLUSIONS:

S100B was not specific for mild brain injuries and may also be elevated after OI. The group-specific association between S100B and ongoing cognitive PCS in children after mTBI should motivate to examine further the role of S100B as a diagnostic biomarker in paediatric mTBI.

• Authors: Martina Studer, Barbara Goeggel Simonetti, Theda Heinks, Maja Steinlin, Alexander Leichtle, Steffen Berger, Alexander Joeris
• Journal: Brain injury (Brain Inj) Vol. 29 Issue 13-14 Pg. 1667-73 ( 2015) ISSN: 1362-301X [Electronic] England
• PMID: 26502808 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• S100 Calcium Binding Protein beta Subunit
• S100B protein, human

Topics

• Adolescent
• Brain Concussion (blood, psychology)
• Brain Injuries (blood, psychology)
• Child
• Child, Preschool
• Cognition Disorders (blood, psychology)
• Female
• Glasgow Coma Scale
• Humans
• Longitudinal Studies
• Male
• Memory Disorders (blood, psychology)
• Neuropsychological Tests
• Post-Concussion Syndrome (blood, psychology)
• Prospective Studies
• S100 Calcium Binding Protein beta Subunit (blood)
• Surveys and Questionnaires
• Treatment Outcome