The work is dedicated to the research of the content of
lipids and products of their peroxidation in rats thymocytes in experimental ulceration. It was found significant increase of the content of lipid peroxidation products diene conjugates (DC),
malondialdehyde (MDA),
schiff base (SB) in experimental models of
gastric ulcers (
ethanol and stress). It was established that under
ethanol gastric the contents of DC increases by 1.8 times, MDA by 2.1 and SB by 1.3 times relative to control values. Under stress model it was observed an increase in the number of DC by 2 times, MDA by 1.9 and SB by 1.3 times relative to control. When
ethanol and stress
ulcers cholesterol increased by 1.7 and 1.5 times,
triacylglycerol by 2 and 2.3 times and
fatty acids by 2.2 and 1.9 times, respectively, relative to controls.
Phosphatidylethanolamine content decreases by 1.5 and 1.3 times compared to control. Also, the stress model, it was observed reduction of
phosphatidylinositol by 1.3 times and increased lizofosfatydylholinu by 1.7 times compared to control. Therefore, our studies indicate quantitative changes of
lipid content (neutral- and
phospholipids) in rats' thymocytes under experimental (
ethanol and stress) ulceration. The reason of this changes may be activation of lipid peroxidation, as shown by the increase of lipid peroxidation products' (DK, MDA, SB) content.