A STAT1-gain-of-function mutation causing Th17 deficiency with chronic mucocutaneous candidiasis, psoriasiform hyperkeratosis and dermatophytosis.

Abstract

During recent years, inborn errors of human IL-17 immunity have been demonstrated to underlie primary immunodeficiencies with chronic mucocutaneous candidiasis (CMC). Various defects in receptors responsible for sensing of Candida albicans or downstream signalling to IL-17 may lead to susceptibility to Candida infection. While CMC is common in patients with profound T cell immunodeficiencies, CMC is also recognised as part of other immunodeficiencies in syndromic CMC, or as relatively isolated CMC disease. We describe a 40-year-old woman with a clinical picture involving cutaneous bacterial abscesses, chronic oral candidiasis and extensive dermatophytic infection of the feet. By whole exome sequencing, we identified a STAT1-gain-of-function mutation. Moreover, the patient's peripheral blood mononuclear cells displayed severely impaired Th17 responses. The patient was treated with antifungals and prophylactic antibiotics, which led to resolution of the infection. We discuss the current knowledge within the field of Th17 deficiency and the pathogenesis and treatment of CMC.

• Authors: Jakob Nielsen, Emil Kofod-Olsen, Eva Spaun, Carsten S Larsen, Mette Christiansen, Trine Hyrup Mogensen
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2015 (Oct 22 2015) ISSN: 1757-790X [Electronic] England
• PMID: 26494717 (Publication Type: Case Reports, Journal Article)
• Copyright: 2015 BMJ Publishing Group Ltd.

Chemical References

• Anti-Bacterial Agents
• Antifungal Agents
• IL17A protein, human
• Interleukin-17
• STAT1 Transcription Factor
• STAT1 protein, human

Topics

• Abscess (diagnosis, drug therapy, genetics)
• Adult
• Anti-Bacterial Agents (therapeutic use)
• Antifungal Agents (therapeutic use)
• Candidiasis, Chronic Mucocutaneous (diagnosis, drug therapy, genetics)
• Female
• Foot Dermatoses (diagnosis, drug therapy, genetics)
• Humans
• Interleukin-17 (deficiency)
• Keratoderma, Palmoplantar, Epidermolytic (diagnosis, drug therapy, genetics)
• Mutation
• STAT1 Transcription Factor (genetics)
• Skin Diseases, Infectious (diagnosis, drug therapy, genetics)
• Tinea (diagnosis, drug therapy, genetics)