Splenectomy is associated with a higher risk for venous thromboembolism: A prospective cohort study.
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| Abstract | BACKGROUND:
Thrombocytosis following splenectomy is a common occurrence. Whether this thrombocytosis leads to a higher risk for venous thromboembolism (VTE) remains unclear. This investigation aimed to determine if splenectomy increases the risk for VTE. METHODS: This was a prospective study conducted in the SICU between 1/2011 and 11/2013 investigating the VTE risk in patients undergoing a splenectomy compared with those undergoing any other abdominal procedure. RESULTS: In total 2503 patients were admitted to the SICU: 37 (2%) after a splenectomy and 638 (26%) after any other abdominal surgery. Splenectomy patients had a higher incidence of VTE compared to patients undergoing any other abdominal procedure (29.7% vs. 12.1%, p < 0.01). After adjustment, splenectomy was associated with a higher adjusted risk for VTE compared to the no-splenectomy group (AOR [95% CI]: 2.6 [1.2, 5.9], p = 0.02). Reactive thrombocytosis did not predict the development of VTE. CONCLUSION:
Splenectomy increases the risk for VTE, however reactive thrombocytosis is not associated with this higher incidence. Further investigations are required to characterize the pathophysiologic mechanisms of VTE development following splenectomy.
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| Authors | Debora H Lee, Galinos Barmparas, Nicole Fierro, Beatrice J Sun, Sogol Ashrafian, Tong Li, Eric J Ley |
| Journal | International journal of surgery (London, England) (Int J Surg) Vol. 24 Issue Pt A Pg. 27-32 (Dec 2015) ISSN: 1743-9159 [Electronic] England |
| PMID | 26493210 (Publication Type: Journal Article, Observational Study) |
| Copyright | Copyright © 2015 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved. |
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