Abstract | BACKGROUND: CASE: A 78-year-old Japanese female with a 2-year history of major depressive disorder was treated with escitalopram (10 mg/d), risperidone (1 mg/d), and nitrazepam (5 mg/d). One month after beginning this drug regimen, she was transferred to the emergency department and immediately hospitalized due to suspicion of a urinary tract infection and dehydration. All psychotropic drugs were discontinued. Five days later, the patient's physical condition had recovered; therefore, the same dose of escitalopram (10 mg/d) was readministered. The patient subsequently developed convulsions accompanied by impaired consciousness, high fever, and myoclonus of both upper extremities. The tendon reflexes of both lower extremities were enhanced. Based on these clinical signs and symptoms, we suspected serotonin syndrome; therefore, escitalopram was discontinued, and a fluid infusion was initiated. The patient recovered from all symptoms within 3 weeks without receiving additional antidepressants. CONCLUSION:
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Authors | Yasushi Sato, Kazuhiko Nakamura, Norio Yasui-Furukori |
Journal | Neuropsychiatric disease and treatment
(Neuropsychiatr Dis Treat)
Vol. 11
Pg. 2505-7
( 2015)
ISSN: 1176-6328 [Print] New Zealand |
PMID | 26491328
(Publication Type: Case Reports)
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